{"id":1130,"date":"2025-07-08T08:09:41","date_gmt":"2025-07-08T08:09:41","guid":{"rendered":"https:\/\/pharmacosmosmedical.com\/staging\/1978\/?page_id=1130"},"modified":"2026-03-30T09:58:56","modified_gmt":"2026-03-30T09:58:56","slug":"clinical-trials","status":"publish","type":"page","link":"https:\/\/pharmacosmosmedical.com\/staging\/1978\/clinical-trials\/","title":{"rendered":"Clinical Trials"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Course Hero” _builder_version=”4.23.3″ use_background_color_gradient=”on” background_color_gradient_stops=”#131b68 0%|#9271f6 100%” background_color_gradient_start=”#474ab6″ background_color_gradient_end=”#9271f6″ background_image=”https:\/\/pharmacosmosmedical.com\/staging\/1978\/wp-content\/uploads\/2023\/07\/coding-background-texture.jpg” background_blend=”overlay” custom_padding=”35px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” da_disable_devices=”off|off|off” locked=”off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”208.5px” custom_padding=”27px|0px|24px|0px” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ header_font=”|on|||” header_text_align=”center” header_font_size=”42px” header_line_height=”1.3em” background_layout=”dark” custom_padding=”|||” header_font_size_tablet=”” header_font_size_phone=”” header_font_size_last_edited=”on|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

Clinical Trials <\/strong><\/h1>\n

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<\/span><\/span>Phase 2 randomized, double-blind, placebo-controlled trials evaluated CKD 4\/6 inhibitor administered prior to chemotherapy in patients with extensive-stage small cell lung cancer. Additional analysis was performed with these data.<\/span><\/p>\n

<\/span><\/span>This section includes links to Pharmacosmos sponsored-publications and selected Pharmacosmos posters. Information contained in these publications may include information that is inconsistent with the FDA approved use of product(s). Pharmacosmos does not recommend the use of its products in a manner that is inconsistent with FDA-approved labeling. Additionally, the content contained in this section is subject to congress copyright permissions.<\/span><\/p>\n

<\/span>Note: Trilaciclib was developed by G1 Therapeutics which is now a subsidiary of Pharmacosmos Therapeutics Inc<\/span><\/span><\/h6>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.23.2″ custom_margin=”|||” custom_padding=”40px|0px|46px|0px||” da_disable_devices=”off|off|off” global_colors_info=”{}” da_is_popup=”off” da_exit_intent=”off” da_has_close=”on” da_alt_close=”off” da_dark_close=”off” da_not_modal=”on” da_is_singular=”off” da_with_loader=”off” da_has_shadow=”on”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

<\/span><\/span>Trilaciclib<\/strong><\/h4>\n

Prescribing Information<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ make_equal=”on” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.23.3″ custom_padding=”|||” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb _builder_version=”4.27.4″ body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” custom_margin=”||42px||false|false” custom_padding=”20px|20px|20px|20px|true|true” locked=”off” global_colors_info=”{}”]<\/p>\n

October 2021<\/span> I Int J Cancer
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Exploratory composite endpoint demonstrates benefit of trilaciclib across multiple clinically meaningful components of myeloprotection in patients with small cell lung cancer<\/strong><\/p>\n

G\u00f3mez MD, Cs\u0151szi T, Jaal J , et al.<\/p>\n

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September 2021 I Cancer Med<\/span>
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Trilaciclib prior to chemotherapy reduces the usage of supportive care interventions for chemotherapy-induced myelosuppression in patients with small cell lung cancer: Pooled analysis of three randomized phase 2 trials<\/span><\/strong>
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Ferrarotto R, Anderson I, Medgyasszay B, et al. <\/span>
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[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”|20px|20px|20px|false|true” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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September 2021 I Clin Lung Cancer<\/span>
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Effects of Trilaciclib on Chemotherapy-Induced Myelosuppression and Patient-Reported Outcomes in Patients with Extensive-Stage Small Cell Lung Cancer: Pooled Results from Three Phase II Randomized, Double-Blind, Placebo-Controlled Studies<\/span><\/strong>
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Weiss J, Goldschmidt J, Andric Z, et al.<\/span>
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[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”|20px|20px|20px|false|true” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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August 2021 I Cancer Manag Res
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Myeloprotective effects of trilaciclib among patients with small cell lung cancer at increased risk of chemotherapy-induced myelosuppression: Pooled results from three phase 2, randomized, double-blind, placebo-controlled studies<\/strong><\/p>\n

Hussein M, Maglakelidze M, Richards DA, et al.<\/p>\n

[\/et_pb_blurb][et_pb_blurb icon_placement=”left” content_max_width=”1100px” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131b68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” min_height=”20px” custom_margin=”-16px||7px||false|false” custom_padding=”17px||9px||false|false” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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May 2021 I Int J Cancer<\/span><\/p>\n

Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: A multicentre, randomised, double-blind, placebo-controlled Phase II trial<\/span><\/strong><\/p>\n

Daniel D, Kuchava V, Bondarenko I, , et al.<\/span><\/p>\n

[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”|20px|20px|20px|false|true” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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January 2021 I Adv Ther<\/span><\/p>\n

Myelopreservation with Trilaciclib in Patients Receiving Topotecan for Small Cell Lung Cancer: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II Stud<\/span><\/strong><\/p>\n

Hart LL, Ferrarotto R, Andric ZG, et al.<\/span><\/p>\n

[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”|20px|20px|20px|false|true” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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October 16-17, 2020 | IASLC North America Conference on Lung Cancer (Poster)<\/p>\n

Trilaciclib has myelopreservation benefits in patients with small cell lung cancer treated with chemotherapy, irrespective of age<\/strong><\/p>\n

Beck JT, Richards DA, Agajanian R, et al.<\/p>\n

[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”-6px||||false|false” custom_padding=”16px||15px||false|false” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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October 16-17, 2020 | IASLC North America Conference on Lung Cancer (Poster)<\/p>\n

Using an exploratory composite endpoint to evaluate the myelopreservation benefits of trilaciclib in patients with small cell lung cancer<\/strong><\/p>\n

Subramanian J, Jaal J, Kudaba I, et al.<\/p>\n

[\/et_pb_blurb][et_pb_blurb icon_placement=”left” _builder_version=”4.27.4″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#131B68″ body_font_size=”16px” body_line_height=”1.5em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||||false|false” custom_padding=”|20px|20px|20px|false|true” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

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October 2019 I Ann Oncol<\/span><\/p>\n

Myelopreservation with the CDK4\/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib\/randomized phase II trial<\/span><\/strong><\/p>\n

Weiss JM, Csoszi T, Maglakelidze M, et al.<\/span><\/p>\n

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